Mohammad Mehdi Shahjamali  Michel Bosman  Shaowen Cao  Xiao Huang  Xiehong Cao  Hua Zhang  Stevin Snellius Pramana  Can Xue 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(17):2880-2886

Ultrathin triangular gold nanoframes are synthesized in high yield through selective gold deposition on the edges of triangular silver nanoprisms and subsequent silver etching with mild wet etchants. These ultrathin gold nanoframes are surfactant‐free with tailorable ridge thickness from 1.8 to 6 nm and exhibit adjustable and distinct surface plasmon resonance bands in the visible and near‐IR region. In comparison, etching of the nanoprism template by galvanic replacement can only create frame structures with much thicker ridges, which have much lower catalytic activity for 4‐nitrophenol reduction than the ultrathin gold nanoframes.  相似文献   

    

Su‐Ting Han  Ye Zhou  Zong‐Xiang Xu  Long‐Biao Huang  Xiong‐Bo Yang  V. A. L. Roy 《Advanced materials (Deerfield Beach, Fla.)》2012,24(26):3556-3561

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Chao Wang  Sheng Peng  Ryan Chan  Shouheng Sun 《Small (Weinheim an der Bergstrasse, Germany)》2009,5(5):567-570

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Wang ZW  Toikkanen O  Quinn BM  Palmer RE 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(11):1542-1545

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Woo JR  Lim DK  Nam JM 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(5):648-655

A gold nanoparticle-based colorimetric antibody structure and activity evaluation method is developed without using complicated and expensive instrumentation. In this assay, a minimum number of antibodies to stabilize nanoparticles are conjugated to gold nanoparticles to prepare minimally stable nanoparticle probes, and the addition of salt rapidly induced particle aggregation and a color change of the solution from red to blue (25-min assay time). It is found that the solution color change is affected by the degree of structural denaturation of antibodies, and the conformational change of antibodies affects the modification of antibodies to nanoparticles and particle stability. Importantly, the colorimetric method can be applied to different types of antibodies (IgG, IgA, and IgM) and it shows comparable or better structural sensitivity than conventional circular dichroism spectroscopy. Moreover, immunoassay results show that these structural changes of antibodies are highly correlated with their antigen-binding activities. Rapid particle aggregation and high structural sensitivity are achieved in this assay because particles are modified with a minimum number of antibodies to stabilize particles in solution. This nanoparticle-based colorimetric method could be useful in evaluating the structural and activity changes of an array of antibodies in an easy, rapid, and sensitive manner.  相似文献   

    

Zan R  Bangert U  Ramasse Q  Novoselov KS 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(20):2868-2872

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Tabakman SM  Chen Z  Casalongue HS  Wang H  Dai H 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(4):499-505

Surface-enhanced Raman scattering (SERS) vastly improves signal-to-noise ratios as compared to traditional Raman scattering, making sensitive assays based upon Raman scattering a reality. However, preparation of highly stable SERS-active gold substrates requires complicated and expensive methodologies and instrumentation. Here, a general and completely solution-phase, seed-based approach is introduced, which is capable of producing gold films for SERS applications on a variety of substrates, not requiring surface modification or functionalization. SERS enhancement factors of ≈10(7) were observed. Moreover, solution-phase gold film deposition on highly complex surfaces, such as protein-coated bioassays, is demonstrated for the first time. Protein bioassays coated with such SERS-active gold films are combined with bioconjugated single-walled carbon nanotube Raman labels, affording highly sensitive detection of the cancer biomarker, carcinoembryonic antigen in serum, with a limit of detection of ≈5 fM (1 pg mL(-1) ).  相似文献   

    

Jang B  Kim YS  Choi Y 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(2):265-270

The photothermal properties of gold nanorods (GNRs) provide an opportunity for the clinical application of highly efficient and tumor-specific photothermal therapy. For the effective hyperthermic ablation of tumor tissue using GNRs, it is essential to maintain a homogeneous therapeutic temperature in the target tissue during treatment. This study investigates whether the concentration of GNRs affects the distribution of the temperature increase during hyperthermal therapy. The investigation is conducted using polyacrylamide phantoms containing varying amounts of GNRs. In 0.1, 0.25, and 0.5 nM GNR-suspended phantoms, the change in temperature is relatively uniform along the depth of each phantom during laser irradiation at 2 W cm(-2) . In 1.0, 2.0, and 5.0 nM GNR-suspended phantoms, the rates of temperature increase in the deep regions of the phantoms decrease with increasing GNR concentration. At a laser irradiation of 5 W cm(-2) , the temperature of the GNR-suspended phantoms increases at a faster rate, whereas the range of GNR concentrations for maintaining the homogeneity of the temperature increase is not affected. This suggests that the concentration of GNRs is the major determinant of the depth-related temperature increase during hyperthermic ablation. Therefore, prior to the clinical application of hyperthermic ablation using GNRs, the concentration of GNRs has to be optimized to ensure a homogeneous distribution of therapeutic temperature in the targeted tissue.  相似文献   

    

Voliani V  Ricci F  Signore G  Nifosì R  Luin S  Beltram F 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(23):3271-3275

Yellow-green controlled photorelease: probes click-linked to peptide-coated gold nanospheres by a triazole ring can be released in living cells under a focused 561 nm laser at low power. Photocleaving follows a three-photon event stimulated by the excitation of the localized surface plasmon resonance.  相似文献   

    

Anant K. Singh  Wentong Lu  Dulal Senapati  Sadia Afrin Khan  Zhen Fan  Tapas Senapati  Teresa Demeritte  Lule Beqa  Paresh Chandra Ray 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(17):2517-2525

A recent gold nanotechnology‐driven approach opens up a new possibility for the destruction of cancer cells through photothermal therapy. Ultimately, photothermal therapy may enter into clinical therapy and, as a result, there is an urgent need for techniques to monitor the tumor response to therapy. Driven by this need, a nanoparticle surface‐energy‐transfer (NSET) approach to monitor the photothermal therapy process by measuring a simple fluorescence intensity change is reported. The fluorescence intensity change is due to the light‐controlled photothermal release of single‐stranded DNA/RNA via dehybridization during the therapy process. Time‐dependent results show that just by measuring the fluorescence intensity change, the photothermal therapy response during the therapy process can be monitored. The possible mechanism and operating principle of the NSET assay are discussed. Ultimately, this NSET assay could have enormous potential applications in rapid, on‐site monitoring of the photothermal therapy process, which is critical to providing effective treatment of cancer and multidrug‐resistant bacterial infections.  相似文献